//How does manganese produce Parkinsonian syndrome?

How does manganese produce Parkinsonian syndrome?

Mn distributions

Manganese is an essential element in the body at trace levels and is a cofactor in many enzymes and proteins but it is neurotoxic in high amounts, causing symptoms similar to Parkinson’s disease. A team of researchers in Bordeaux in France has now used organelle fluorescence microscopy combined with synchrotron X-ray fluorescence (SXRF) imaging to show that manganese accumulates in the Golgi apparatus of human cells that are transfected with a mutant protein that causes toxic build-up of manganese in cells. The single-cell imaging technique could help us better understand the mechanisms behind neurotoxicity in Parkinsonian syndrome and other neurological diseases.

To read the rest of this article: https://physicsworld.com/a/how-does-manganese-produce-parkinsonian-syndrome/

By | 2019-01-30T20:52:54+00:00 January 29th, 2019|Latest news|Comments Off on How does manganese produce Parkinsonian syndrome?

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Bel Dumé, science writer/editor